“3-FPM acts as a norepinephrine-dopamine releasing agent with EC50 values of 43 nM and 30 nM, respectively. It shows only negligible efficacy as a releaser of serotonin, with an EC50 value of 2558 nM.
3-FPM also inhibits uptake mediated by dopamine transporters and norepinephrine transporters in HEK293 cells […] (IC50 values < 2.5 μM), but with less potent effects at serotonin transporters (IC50 values >80 μM).
At sufficient doses, 3-FPM is capable of reversing monoamine transporters, particularly transporters of the catecholamines dopamine and norepinephrine, and, to a much lesser degree, serotonin transporters, thereby releasing these neurotransmitters from the cytosol into the extracellular space, where they are active.
Evaluation of its metabolic pathway revealed N‐oxidation, aryl hydroxylation and subsequent O‐methylation, alkyl hydroxylation, oxidation, and degradation of the ethyl‐bridge yielding the O/N‐bis‐dealkylated metabolite, combinations thereof and further glucuronidation or sulfations.“
-Excerpt from WikiPedia
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